李凯(副研究员,硕士生导师)

研究方向:消化道肿瘤代谢与治疗
教育科研经历:
2006年09月—2010年07月,吉林大学,学士
2011年09月—2016年07月,中山大学,博士
2016年08月—2019年12月,中山大学,博士后
2020年01月—至今,中山大学附属第六医院,副研究员
2016年研究生毕业于中山大学中山医学院药理学专业(国家重点学科),获博士学位。2020年1月获评中山大学附属第六医院首位转聘副研究员,任硕士生导师。主要从事肿瘤生物治疗与肿瘤代谢的研究,近五年发表SCI论文20余篇,其中IF>10分十五篇。以第一作者/通讯作者研究论文发表在Cell Research、Science Translational Medicine、PNAS、Signal Transduction & Targeted Therapy、Cell Reports(2篇), eBiomedicine, Journal of Virology、Gut Microbes、Molecular Therapy 和 Stem Cell Research and Therapy等国际权威期刊上,其中Cell Research原创论文获得“中国细胞生物学学会青年优秀论文奖”;Science Translational Medicine 上发表的原创性论文被nature reviews专题评述,高度肯定了该论文的重要性。主持国家自然科学基金青年项目一项,广东省自然科学基金面上项目一项,广东省自然科学基金青年提升项目一项,广州市重点研发课题骨干,中国博士后基金项目两项(面上项目和特别资助)。作为主要发明人授权国际专利和中国专利多项,并获中国专利银奖


代表性论文代表性项目荣誉

1.Kai Li#, Jian-lin Wu#, Baifu Qin,  Zongmin Fan, Qin Tang, Weisi Lu, Haipeng Zhang, Fan Xing, Manqi Meng, Shaomin Zou, Wenxia Wei, Honglei Chen, Jian Cai, Huaimin Wang, Hui Zhang, Jiayue Cai, Ling Fang, Xiqing Bian, Chuangqi Chen, Ping Lan, Bart Ghesquière,Lekun Fang*, and Mong-Hong Lee*. ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer. Cell Research. ISSN: 1748-7838. 2020, 30(2). 
2.Youwei Huang#, Fang Wang#, Xi Lin#, Qing Li, Yuli Lu, Jiayu Zhang, Xi Shen, Jingyi Tan, Zixi Qin, Jiahong Chen, Xueqin Chen, Guopeng Pan, Xiangyu Wang, Yuequan Zeng, Shangqi Yang, Jun Liu, Fan Xing*, Kai Li* and Haipeng Zhang*. Nuclear VCP drives colorectal cancer progression by promoting fatty acid oxidation. Proceedings of the National Academy of Sciences of the United States of America, 2023.
3.Wenxia Wei#, Baifu Qin#, Weijie Wen#, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jiang, Mengan Wang, Qin Tang, Runxiang Yang, Zongmin Fan, Haiwen Lyu, Jiayu Zhang, Junzhong Lin, Kai Li* and Mong-Hong Lee*. FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth. Signal Transduction and Targeted Therapy, 2023.
4.Haipeng Zhang#, Kai Li#, Yuan Lin#, Fan Xing, Xiao Xiao, Jing Cai, Wenbo Zhu, Jiankai Liang, Yaqian Tan, Liwu Fu, Fang Wang, Wei Yin, Bingzheng Lu, Pengxin Qiu, Xingwen Su, Shoufang Gong, Xuetao Bai, Jun Hu* and Guangmei Yan*. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma. Science Translational Medicine. ISSN: 1946-6242. 2017, 9(404). 
5.Weili Wu#, Yingying Zhao#, Baifu Qin#, Xin Jiang, Chuyue Wang, Rong Hu, Rui Ma, Mong-Hong Lee, Huanliang Liu, Kai Li* and Ping Yuan*. Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer. eBioMedicine, 2023.
6.Si-cheng Liu, Rui Guo, Hui Xu, Hai-dan Luo, Jin-neng Yang, Hai-dan Luo, Kai Li, Sai-Ching Jim Yeung, Kai Li*, Mong-hong Lee* and Run-xiang Yang*. 14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer. Cell Reports, 2023. 
7.Ziyu, Huang#, Yue Li#, Heekuk Park, Martin Ho, Kanchan Bhardwaj, Naoki Sugimura, Hye Won Lee, Huicui Meng, Mattias P. Ebert, Kang Chao, Elke Burgermeister, Aadra P. Bhatt, Sudarshan A. Shetty, Kai Li*, Weiping Wen* and Tao Zuo*. Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanisation. Gut Microbes, 2023. 
8.Fang Wang#, Qi Qi#, Baifu Qin#, Yiwei Wang, Youwei Huang, Qing Li, Xi Shen, Xiangyu Wang, Shangqi Yang, Guopeng Pan, Jiahong Chen, Zixi Qin, Xueqin Chen, Yuqing Yang, Yuequan Zeng, Jun Liu, Yuqin Li, Ying Li, Zexiong Cheng, Xi Lin, Fan Xing, Yubo Zhang, Guocai Wang, Kai Li*, Zhenyou Jiang* and Haipeng Zhang*. Targeting VCP potentiates immune checkpoint therapy for colorectal cancer. Cell Reports, 2023.
9.Kai Li#, Haipeng Zhang#, Jianguang Qiu, Yuan Lin, Jiankai Liang, Xiao Xiao, Liwu Fu, Fang Wang, Jing Cai, Yaqian Tan, Wenbo Zhu, Wei Yin, Bingzheng Lu, Fan Xing, Lipeng Tang, Min Yan, Jialuo Mai, Yuan Li, Wenli Chen, Pengxin Qiu, Xingwen Su, Guangping Gao, Phillip WL Tai, Jun Hu* and Guangmei Yan*. Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1. Molecular Therapy: the journal of the American Society of Gene Therapy. 2016. 
10.Kai Li#, Cheng Hu#, Fan Xing#, Mingshi Gao, Jiankai Liang, Xiao Xiao, Jing Cai, Yaqian Tan, Jun Hu, Wenbo Zhu,Wei Yin, Yuan Li, Wenli Chen, Bingzheng Lu, Jialuo Mai, Pengxin Qiu, Xingwen Su, Guangmei Yan, Haipeng Zhang* and Yuan Lin*. Deficiency of the IRE1 alpha-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1. Journal of Virology. 2018. 
11.Baifu Qin #, Shaomin Zou #, Kai Li #, Huashe Wang, Wenxia Wei, Boyu Zhang, Lishi Xiao, HyunHo Choi, Qin Tang, Dandan Huang, Qingxin Liu, Qihao Pan, Manqi Meng, Lekun Fang * and Mong-Hong Lee*. CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis. British Journal of Cancer. 2020. 
12.Lifei Zhu#, Xi Lin#, Lin Zhi, Yushan Fang, Keming Lin, Kai Li*, and Liangcai Wu*. Mesenchymal stem cells suppress vitiligo progression through PTEN pathway. Stem Cell Research and Therapy. 2019.