杨孜欢 (研究员，博士生导师，博士后合作导师)

代表性论文：

1.Jiang Xuefei; Yang Lanlan; Chen Guanxing; Feng Xingzhi; Liu Yiting; Gao, Qianling; Mai Mingru; Chen Calvin Yu-Chian; Ye Shubiao; Yang Zihuan*; Discovery of Kinetin in inhibiting colorectal cancer progression via enhancing PSMB1-mediated RAB34 degradation. Cancer Lett. 2024

2.Ye SB, Cheng YK, Li PS, Zhang L, Zhang LH, Huang Y, Chen P, Wang Y, Wang C, Peng JH, Shi LS, Ling L, Wu XJ*, Qin J*, Yang Zihuan*, Lan P*. High-throughput proteomics profiling-derived signature associated with chemotherapy response and survival for stage II/III colorectal cancer. NPJ Precis Oncol. 2023;7(1):50. 

3.Liu Yiting, Gao, Qianling, Feng Xingzhi, Chen Guanxing, Jiang Xuefei, Chen Daici, Yang Zihuan*. Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/beta-catenin signaling activation. Gastroenterol Rep (Oxf). 2023;11:goad033. 

4.Xu Dong, Feng Xingzhi, Wan Yuxin, Yang Lanlan, Gao Qianling, Yang Zihuan*, Du Chang*. Curcumin nano-prodrug induces multi-phase cell cycle arrest in colorectal cancer through suppression of CDKs and specific down-regulation of PLK1. Smart Materials in Medicine. 2023;4:648-60.

5.Liu Binbin; Liu Tengfei; Liu Yiting; Feng Xingzhi; Jiang Xuefei; Long, Jiahui; Ye Shubiao; Chen Daici; Wang, Jianping; Yang Zihuan*; TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer, Int J Biol Sci, 2022, 18(4): 1677-1694 

6.Jiang Xuefei; Yang Lanlan; Gao, Qianling; Liu Yiting; Feng Xingzhi; Ye Shubiao; Yang Zihuan*; The Role of RAB GTPases and Its Potential in Predicting Immunotherapy Response and Prognosis in Colorectal Cancer, Front Genet  2022, 13: 828373 

7.Liu, Tengfei, Liu, Binbin, Liu Yiting, Feng Xingzhi, Jiang Xuefei, Long, Jiahui, Gao, Qianling, Yang Zihuan*, Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis. Cancer Cell Int. 2021; 21:287 

8.Chen Daici, Li, Yichen, Zhang, Xiaowen, Wu, Haiyong, Wang, Qian, Cai, Jian, Cui, Yanmei, Liu, Huanliang, Lan, Ping, Wang, Jianping, Yang Zihuan*, Wang, Lei*, Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation. Oncogene. 2019;38 (37):6429-44

9.Huang Dandan, Feng Xingzhi, Liu Yiting, Deng Yanhong, Chen Hao, Chen Daici, Fang Lekun, Cai Yue, Liu Huanliang, Wang Lei, Wang Jianping*, Yang Zihuan*. AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer. Cell Death Dis. 2017;8(6):e2894. doi: 10.1038/cddis.2017.282

10.Fang Lekun#，Yang Zihuan#，Zhou Junyi，Tung Jung-Yu，Hsiao Chwan-Deng，Wang Lei，Deng Yanhong，Wang Puning，Wang Jianping*，Lee Mong-Hong*，Circadian Clock Gene CRY2 Degradation Is Involved in Chemo-resistance of Colorectal Cancer. Mol Cancer Therap 2015;14(6):1476-87 

11.Yang Zihuan*，Pan Ao，Zuo Wulin，Guo Jinghui，Zhou Wenliang*，Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle. J Ethnopharm. 2014，155（2）：1177-1183 

专利

1.杨孜欢; 刘腾飞; 刘彬彬; 冯杏芝; 刘依婷; 蒋雪飞 ; GOLT1B抑制剂在制备治疗结直肠癌药物中的应用, 2020-10-13, 中国, 202011087782.9 (发明专利)

2.杨孜欢; 刘彬彬; 刘腾飞; 冯杏芝; 刘依婷; 蒋雪飞 ; TSG-6基因在预测结直肠癌转移及预后方面的应用, 2020-10-29, 中国, 202011178863.X (发明专利)

3.杨孜欢; 蒋雪飞; 一种用于预防和/或治疗CRC的小分子药物, 2022-07-29，202210913120.5 (发明专利，授权)

1.国家自然科学基金面上项目、2024-01-01到2027-12-31、主持；

2.广东省自然科学基金面上项目、2024-01-01到2026-12-31、主持；

3.广州市重点研发项目、2024-01-01到2026-12-31、主持；

4.广东省自然科学基金面上项目、2021-01-01到2023-12-31、主持；

5.广东省海外名师项目、2020-09-01 到 2021-08-31、主持；

6.国家自然科学基金青年项目、2018-01-01到2020-12-31、主持；

7.广东省自然科学基金博士启动项目、2017-01-01到2019-12-31、主持；

8.广州市科技计划科学研究专项、2016-01-01到2018-12-31、主持；

1.基于肛门功能和性功能保护的直肠癌治疗关键技术创新与推广应用.中华人民共和国国务院国家科技进步二等奖，2016.12.21（汪建平，兰平，王磊，吴小剑，邓艳红，黄美近，汪挺，杨孜欢，方乐堃，王辉）

2.结直肠肿瘤防治的关键技术创新与应用推广,中华医学会,中华医学科技奖医学科学技术奖, 省部二等奖, 2019 (兰平，汪建平，邹鸿志，邓艳红，王磊，康亮，吴小剑，杨孜欢，骆衍新，黄美近).

3.结直肠癌筛查方案和治疗策略的技术创新，教育部，高校科研优秀成果奖科技进步一等奖，2020 (兰平，吴小剑，邓艳红，康亮，杨孜欢，邹鸿志，方乐堃，黄美近，汪建平，何小文，杨祖立)