左涛(研究员,博士生导师)

      左涛教授担任广东省胃肠病学研究所副所长,为美国消化协会颁发的“青年研究奖”获得者、香港中文大学研究计划奖获得者、欧洲克罗恩病与结肠炎委员会(ECCO)青年委员。

      现任Frontiers in Nutrition、Frontiers in Cellular and Infection Microbiology 特邀副主编,10余本英文杂志编委会委员。拥有5项美国PCT专利。

      以第一作者/并列第一作者、通讯作者发表英文文章30余篇,其中影响因子大于10的文章14余篇,包括Gut (IF 19.8)、Gastroenterology (IF 17.4)、Cell Host & Microbe (IF 15.9)、Nature Communications (IF 12.1)、Nature Reviews Gastroenterology & Hepatology (IF 29.8)、Microbiome (IF 11.6) 等。以参与作者在Nature Genetics 等杂志发表文章10余篇。

团队研究方向:

1.肠道微生态(细菌、噬菌体、真菌)与人体健康的关系

2.肠道微生态(细菌、噬菌体、真菌)在炎症性肠病(IBD)和粪菌移植(FMT)中的作用

3.应用宏基因组学、微生物组学、代谢组学、蛋白组学、转录组学等多组学手段和分子生物学、动物生理学揭示肠道微生物与宿主整体免疫和粘膜免疫的关系

4.通过转化医学(临床医学和基础医学)研究实现肠道微生态与消化道内、外疾病的致病机理和治疗的探索

实验室网址:www.zuotaolab.com

ORCID identifier: 0000-0001-8450-5281

PI教育和研究背景

2018.11-2020.12.21     香港中文大学,医学院               研究助理教授

2019.11-2020.12.21     香港肠道微生物研究MAGIC中心        科学家

2018.11-2020.12.21     香港中文大学,肠道微生物研究中心    研究助理教授

2015.11-2018.11       香港中文大学,医学院                   博士后

2014.8-2015.3         哈佛大学医学院、波士顿儿童医院      联合培养博士

2010.9-2015.6         中国海洋大学,食品科学                硕博连读

2006.9-2010.6         中国海洋大学,生物工程                  本科


代表性论文代表性项目荣誉


第一作者(包含并列第一, IF>10):

1.Tao Zuo#, Qin Liu#, Fen Zhang# et al. Depicting SARS-CoV-2 fecal viral activity in association with gut microbiota composition in patients with COVID-19. Gut (2020). (影响因子: 19.819, 杂志排名: 1/145 in gastroenterology)

2.Tao Zuo#, Yang Sun#, Yating Wan et al. Human Gut DNA Virome Variations across Geography, Ethnicity, and Urbanisation. Cell Host & Microbe (2020). (CELL子刊,影响因子: 15.923, 杂志排名: 4/158 in microbiology)

3.Tao Zuo#, Fen Zhang# et al. Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. Gastroenterology (2020). https://doi.org/10.1053/j.gastro.2020.05.048. (影响因子: 17.373, 杂志排名: 2/145 in gastroenterology)

4.Tao Zuo#, Hui Zhan# et al. Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalisation until Discharge. Gastroenterology (2020). (影响因子: 17.373, 杂志排名: 2/145 in gastroenterology)

5.Tao Zuo, Siew C Ng et al. Gut mucosal virome alterations in ulcerative colitis. Gut (2019): gutjnl-2018. (影响因子: 19.819, 杂志排名: 1/145 in gastroenterology)

6.Tao Zuo, Siew C Ng. Authors response: giant oversights in the human gut virome. Gut, gutjnl-2019. (2019)  (影响因子: 19.819, 杂志排名: 1/145 in gastroenterology)

7.Tao Zuo, Michael A. Kamm, Jean-Frédéric Colombel, Siew C Ng. Urbanization and the gut microbiota in health and inflammatory bowel disease. Nature Reviews Gastroenterology & Hepatology, 2018, 1. doi:10.1038/s41575-018-0003-z. (影响因子: 29.848, 杂志排名: 3/145 in gastroenterology)

8.Tao Zuo, Wong S H, Lam K, Siew C Ng et al. Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome. Gut, 2018, 67(4):634-643. (影响因子: 19.819, 杂志排名: 1/145 in gastroenterology)

9.Tao Zuo, Sunny H Wong, Siew C Ng et al. Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nature Communications, 2018, doi: 10.1038/s41467-018-06103-6. (影响因子: 12.121, 杂志排名: 3/145 in Multidisplinary)

10.Fen Zhang#, Tao Zuo#, Yun Kit Yeoh#, et al. Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease.Nature Communications (影响因子: 12.121, 并列第一). 

11.Yang Sun#, Tao Zuo#, et al. Population-level configurations of gut mycobiome across six ethnicities in urban and rural China.Gastroenterolgoy (影响因子: 17.373, , 杂志排名: 2/145 in gastroenterology, 并列第一) 

12.Yun Kit Yeoh#, Tao Zuo#, et al. Gut microbiota composition reflects disease severity and dysfunctional immune responses in COVID-19 patients. Gut (2020). (影响因子: 19.819, 杂志排名: 1/145 in gastroenterology, 并列第一)

13.Tao Zuo#, Liu Q#, Zhang F#, et al. Temporal Landscape of Human Gut virome in SARS-CoV-2 infection and severity. Microbiome. (2021). In press. (共同第一,影响因子: 11.607, 杂志排名: 3/128 in Microbiology (medical))

14. Tao Zuo, Yun Kit Yeoh, Siew C Ng. Reply: The New Foe and Old Friends: Are We Ready for Microbiota-based Therapeutics in Treating COVID-19 Patients? Gastroenterolgoy (2021). (影响因子: 17.373, , 杂志排名: 2/145 in gastroenterology)


第一作者(及并列第一, IF<10):

15.Tao Zuo, and Siew C. Ng. The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease. Frontiers in microbiology 9 (2018). (影响因子: 4.235, 杂志排名: 27/129 in gastroenterology)

16.Wu WKK^, Sun R^, Zuo T^, Tian Y^, Zheng Z, Ho J, Wu JCY, Chan FKL, Chan MTV, Yu J, Wong SH*, Wang MH*, Ng SC*. A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese. J Cell Mol Med, 2018, 22(4), 2368-2377. doi: 10.1111/jcmm.13530. (Co-first author) (并列第一,影响因子:4.658, 杂志排名: 38/175)

17.Tao Zuo, R Zhao, S LU, N Zhang, Q Zhang, C Xue. Novel dietary polysaccharide SIP promotes intestinal secretory immunoglobulin A secretion in mice under chemotherapy. Journal of functional foods. 2017,37, 379–389. (影响因子: 3.701, 杂志排名: 41/327 in Food Science)

18.Zuo Tao, Zhang Na, Zhang Qi, et al. Transportation of squid ink polysaccharide SIP through intestinal epithelial cells and its utilization in the gastrointestinal tract. Journal of Functional Foods, 2016, 22: 408-416. (影响因子: 3.701, 杂志排名: 41/327 in Food Science)

19.Tao Zuo, Lu Cao, Xuemin Li, Qi Zhang, Changhu Xue, Qingjuan Tang.  The squid ink polysaccharides protect tight junctions and adherens junctions from chemotherapeutic injury in the small intestinal epithelium of mice.  Nutrition and Cancer. 2015, 67.2:364-371. (影响因子: 2.322, 杂志排名: 63/128 in Nutrition and Dietetics)

20.Tao Zuo, Xuemin Li, Yaoguang Chang, Gaofei Duan, Long Yu, Rong Zheng, Changhu Xue, Qingjuan Tang. Dietary fucoidan of Acaudina molpadioides and its enzymatic degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice. Food and Function. 2015,6, 415-422. (影响因子: 3.701, No. of citation: 5, 杂志排名: 41/327 in Food Science) (影响因子: 4.171, 杂志排名: 36/327 in Food Science)

21.Tao Zuo, Xinjia He, Lu Cao, Changhu Xue, Qingjuan Tang.  Dietary polysaccharide from Ommastrephes bartrami prevents chemotherapeutic mucositis by promoting the genes expression of antimicrobial peptides in paneth cells. Journal of functional foods. 2015, 12:530-539. (影响因子: 3.701, 杂志排名: 41/327 in Food Science)

22.Tao Zuo, Lu Cao, Xuemin Li, Changhu Xue, Qingjuan Tang*.  Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury. Food and function, 2015, 6(3): 981-986. (影响因子: 4.171, 杂志排名: 39/327 in Food Science)

23.Tao Zuo, Xianqi Feng, Na Zhang, Changhu Xue, Qing-Juan Tang*. Establishment of a functional secretory IgA transcytosis model system in vitro for functional food screening. J Applied Microbiology and Biotechnology. 2015, 6(3): 981-986. (影响因子: 3.670, 杂志排名: 41/327 in Food Science)

24.Tao Zuo, Lu Cao, Xianghong Sun, Xuemin Li, Juan Wu, Shangyun Lu, Changhu Xue, and Qing-Juan Tang*. Dietary Squid Ink Polysaccharide Could Enhance Siga Secretion in Chemotherapeutic Mice. Food and Function. 2014, 5(12): 3189-3196. (影响因子: 4.171, 杂志排名: 39/327 in Food Science)

25.Tao Zuo, Zhaojie Li, Yingchun Lv, Gaofei Duan, Chunxia Wang, Qingjuan Tang, Changhu Xue. Rapid identification of sea cucumber species with multiplex-PCR. Food control, 2012, 26(1):58-62. (影响因子: 4.258, 杂志排名: 18/327 in Food Science)

26.Tang, Qingjuan1, Tao Zuo1, Shangyun Lu, Juan Wu, Jianghua Wang, Rong Zheng, Shiguo Chen, and Changhu Xue*. Dietary Squid Ink Polysaccharides Ameliorated the Intestinal Microflora Dysfunction in Mice Undergoing Chemotherapy. Food and function, 2014, 5 (10):2529-35. (并列第一) (影响因子: 4.171, 杂志排名: 39/327 in Food Science)


通讯作者:

27.Zuo T*. Unveiling the gut virome in human health and diseases. Int J Clin Virol. 2018; 2: 001-003. (第一及通讯作者)

28.Tao Zuo*. The Changing Landscape of the Effect of food/diet on the gut Microbiota in Relation to Health and Disease. Nutrition and Food Toxicology, 2017, 2.1: 262-264. (第一及通讯作者)

29.Zhang N, Ju Z, Zuo T*. Time for food: the impact of diet on gut microbiota and human health[J]. Nutrition, 2018. (通讯作者,影响因子:3.639)

30.Shangyun Lu and Tao Zuo*. Effect of Food Additives on the Gut Microbiome in Relation to Human Health. Nutrition and Food Toxicology 2.5 (2018): 474-476. (通讯作者)

31.Fen Zhang, Tao Zuo*. From Gut Microbial Ecogroup to Precision Nutrition and Human Health. Austin J Nutr Metab. 2019; 6(2): 1070. (通讯作者)

32.Hui Zhan, Tao Zuo*. Frontiers in human mycobiome in health and disease. American Journal of Biomedical Science & Research. 2020 - 7(4). AJBSR.MS.ID.001170. DOI:10.34297/AJBSR.2020.07.001170. (通讯作者)

国际论坛演讲

1.Oral presentation: Digestive disease week, Chicago, USA; 2017

Microbiome & Microbial Diseases in the Gastrointestinal Tract, “Bacteriophage transfer during fecal microbiota transplantation is associated with treatment response in Clostridium difficile infection”

2.Oral presentation: Digestive disease week, Washington DC, USA; 2018

Distinguished microbiome plenary session, “Fecal microbiota transplantation alters the gut mycobiome (fungome) which correlates with treatment outcome in Clostridium difficile infections” 

3.Invited speaker: Microiome Science Days, Berchtesgaden, Germany; 2018

“Gut Fungi and Fecal microbiota transplantation” 

4.Oral presentation: Digestive disease week, San Diego, USA; 2019

IBD: Microbiome session, “Increased bacteriophage abundance and loss of viral-bacterial interactions in the mucosa of Ulcerative Colitis: Key to Pathogenesis?” 

5.Oral presentation: Digestive disease week, San Diego, USA; 2019 

Research Forum, Committee Sponsored Symposium; Presentation of Best of AGA (American Gastroenterological Association) at DDW in Chinese

6.Oral presentation: Digestive disease week, Chicago, USA; 2020 

Dark Matter: Nonbacterial Kingdoms of the Gut Microbiome, “The human gut virome is geography and ethnicity specific: population-based viral metagenomics across six ethnicities in rural and urban China” 

7.Invited speaker: Avison Symposium, Seoul, Korea; 2020

Microbiome in Human Health”

8.Invited speaker: Targeting Microbiota 2021 Virtual Congress: October 22-23, 2021, France. International Society of Microbiota. 

Many aspects of the Gut microbiome in Patients With COVID-19.