李孟鸿(教授,博士生导师 )

李孟鸿教授,国家长期创新高层次人才计划入选者,国家特聘专家,中山大学胃肠病学研究所教授。曾任美国最佳癌症中心-MD安德森癌症中心终身正教授。曾任M.D.Anderson癌症中心终身教授评定委员会委员和研究教授评定委员会副主席。李教授一直致力于分子细胞肿瘤学研究,在细胞周期、泛素化调控肿瘤发生发展、肿瘤代谢、肠道微生态等方向系统地开展了深入的探讨。近年来,作为通讯作者(共同)在Cancer Cell、Cell Research、JCI、JNCI、Nature Commun、PNAS等高水平杂志发表相关SCI文章,累计被引用13000余次。2015年获中山大学“百人计划-领军人才”引进全职加入中山大学胃肠研究所。目前已组建了一支年轻的富有潜力的研究队伍,在中山六院已经取得了可喜的研究成果,在结直肠癌泛素化分子标记物和化疗敏感性等领域中以中山大学胃肠研究所为完成单位发表了Cancer Cell、Cell Research、Cell Discovery, Signal Transduction and Targeted Therapy, Nature Communications, Cancer Communications, Advanced Science等多篇高水平论文,并获得了包括国家自然科学基金重点项目在内的多项基金项目。担任Journal of Cancer Science & Therapy、Gastroenterology Report编委以及Nature Review of Cancer、JCI、JNCI、GUT、PNAS等27种国际高水平杂志的审稿人。
教育经历:
1980/09 – 1984/06,台湾大学生命化学系,获理学学士学位
1988/09 – 1993/06,美国匹兹堡大学分子细胞发育生物系,硕博连读,获博士学位,导师:Graham Hatfull教授
工作履历:                                                                       
2015/11至今,中山大学附属第六医院,教授
2010/09 – 2015/10,德克萨斯大学MD安德森癌症中心(The University of Texas MD Anderson Cancer Center, UTMDACC),终身正教授
2004/09 – 2010/08,德克萨斯大学MD安德森癌症中心,副教授
1997/01 – 2004/08,德克萨斯大学MD安德森癌症中心,助理教授
1993/09 – 1996/12,美国纪念斯隆凯特林癌症中心霍华德修斯医学研究所,博士后,导师:Joan Massague教授

代表性论文代表性项目荣誉

1.Huilin Jin#, Xiaoling Huang#, Qihao Pan#, Ning Ma, Xiaoshan Xie, Yue Wei, Fenghai Yu, Weijie Wen, Boyu Zhang, Peng Zhang, Xijie Chen, Jie Wang, Ran-yi Liu, Junzhong Lin, Xiangqi Meng* & Mong-Hong Lee*, The EIF3H-HAX1 axis increases RAF-MEKERK signaling activity to promote colorectal cancer progression, Nature Communications, 2024 Mar 21;15(1):2551. (IF=16.6)
2.Kai Li#, Jiayu Zhang#, Haiwen Lyu#, Jinneng Yang#, Wenxia Wei, Yuzhi Wang, Haidan Luo, Yijing Zhang, Xin Jiang, Hairong Yi, Mengan Wang, Caiyun Zhang, Kang Wu, Lishi Xiao, Weijie Wen, Hui Xu, Guolin Li, Yunle Wan, Fang Yang, Runxiang Yang, Xinhui Fu, Baifu Qin, Zhongguo Zhou,* Haipeng Zhang,* and Mong-Hong Lee*, CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation, Advanced Science, 2024 Feb 2:e2306827. (IF=15.1)
3.Qihao Pan#, Fenghai Yu#, Huilin Jin#, Peng Zhang, Xiaoling Huang, Jingxuan Peng, Xiaoshan Xie, Xiangli Li, Ning Ma, Yue Wei, Weijie Wen, Jieping Zhang, Boyu Zhang, Hongyan Yu, Yuanxun Xiao, Ran-Yi Liu, Qingxin Liu, Xiangqi Meng*, and Mong-Hong Lee*, eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer, Advanced Science, 2023 Sep;10(27):e2300759. (IF=15.1)
4.Wenxia Wei#, Baifu Qin#, Weijie Wen#, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jiang, Mengan Wang, Qin Tang, Jiayu Zhang, Runxiang Yang, Zongmin Fan, Haiwen Lyu, Junzhong Lin, Kai Li* and Mong-Hong Lee*, FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth, Signal Transduction and Targeted Therapy, 2023 May 19;8(1):187. (IF=39.3)
5.Hui Xu, Haidan Luo, Jiayu Zhang, Kai Li, and Mong-Hong Lee, Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer, Gut Microbes, 2023 Jan-Dec;15(1):2186114. (IF=12.2)
6.Boyu Zhang#; Qingxin Liu#*; Weijie Wen#; Han Gao; Wenxia Wei; Aiwen Tang; Baifu Qin; Haiwen L yu; Xiangqi Meng; Kai Li; Huilin Jin; Fenghai Yu; Qihao Pan; Junzhong Lin; Mong-Hong Lee*; The ch romatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitoc hondrial dynamics via EGF and Wnt signaling, Cell Discovery, 2022, 8(130). (IF=33.5)
7.Xiangqi Meng #*, Jingxuan Peng #, Xiaoshan Xie # , Fenghai Yu, Wencong Wang, Qihao Pan, Huilin Jin, Xiaoling Huang, Hongyan Yu, Shengrong Li, Dianying Feng, Qingxin Liu, Lekun Fang*, Mong-Hong Lee*, Roles of lncRNA LVBU in regulating urea cycle/polyamine synthesis axis to promote colorectal carcinoma progression, Oncogene, 2022 Sep;41(36):4231-4243. Epub 2022 Jul 29. (IF=8.0)
8.Mong-Hong Lee#*, Harness the functions of gut microbiome in tumorigenesis for cancer treatment, Cancer Communications, 2021 Oct, 41(10):937-967. (IF=16.2)
9.Ping-Chieh Chou#, Hyun Ho Choi#, Yizhi Huang, Enrique Fuentes-Mattei, Guermarie Velazquez-Torres, Fanmao Zhang, Liem Phan, Jaehyuk Lee, Yanxia Shi, James A Bankson, Yun Wu, Huamin Wang, Ruiying Zhao*, Sai-Ching Jim Yeung*, Mong-Hong Lee*, Impact of diabetes on promoting the growth of breast cancer, Cancer Communications, 2021 May, 41(5):414-431. (IF=16.2)
10.Weixiong Yang#, Chang-Han Chen#*, Minghan Jia#, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung, Mong-Hong Lee*, Chao Cheng*, Tumor-Associated Microbiota in Esophageal Squamous Cell Carcinoma, Frontiers in Cell and Developmental Biology, 2021 Feb 18;9:641270. (IF=5.5)
11.Hyun Ho Choi#, Shaomin Zou, Jian-Lin Wu, Huashe Wang, Liem Phan, Kai Li, Peng Zhang, Daici Chen, Qingxin Liu, Baifu Qin, Thu Anh Thai Nguyen, Sai-Ching J Yeung, Lekun Fang*, Mong-Hong Lee*, EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis, Advanced Science, 2020 Sep 23, 7(20):2000681. (IF=15.1)
12.Kuo-Chang Wen#, Pi-Lin Sung# Alexander T H Wu, Ping-Chieh Chou, Jun-Hung Lin, Chi-Ying F Huang, Sai-Ching J Yeung*, Mong-Hong Lee*, Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer, Journal of Ovarian Research, 2020 Aug 21, 13(1):95. (IF=4.0)
13.Baifu Qin#, Shaomin Zou#, Kai Li#, Huashe Wang, Wenxia Wei, Boyu Zhang, Lishi Xiao, Hyun Ho Choi, Qin Tang, Dandan Huang, Qingxin Liu, Qihao Pan, Manqi Meng, Lekun Fang*, Mong-Hong Lee*, CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis, British Journal of Cancer, 2020 May, 122(11):1673-1685. (IF=8.8)
14.Guermarie Velazquez-Torres#, Enrique Fuentes-Mattei#, Hyun Ho Choi#, Sai-Ching J. Yeung, Xiangqi Meng* and Mong-Hong Lee*, Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth, Gastroenterology Report, 2020 May 27;8(4):261-276. (IF=3.6)
15.Kai Li#; Jian-lin Wu#; Baifu Qin; Zongmin Fan; Qin Tang; Weisi Lu; Haipeng Zhang; Fan Xing; Manqi Meng; Shaomin Zou; Wenxia Wei; Honglei Chen; Jian Cai; Huaiming Wang; Hui Zhang; Jiayue Cai; Ling Fang; Xiqing Bian; Chuangqi Chen; Ping Lan; Bart Ghesquiere; Lekun Fang*; Mong-Hong Lee*,ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer, Cell Research, 2020 Feb, 30(2):163-178. (IF=44.1)
16.Shaomin Zou#, Lekun Fang#, Mong-Hong Lee*, Dysbiosis of gut microbiota in promoting the development of colorectal cancer, Gastroenterology Report, 2018 Feb, 6(1):1-12. (IF=3.6)
17.Lekun Fang#, Weisi Lu#, Hyun Ho Choi, Sai-Ching J Yeung, Jung-Yu Tung, Chwan-Deng Hsiao, Enrique Fuentes-Mattei, David Menter, Chuangqi Chen, Lei Wang, Jianping Wang*, Mong-Hong Lee*, ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development, Cancer Cell, 2015 Aug 10;28(2):183-97. (IF=50.3)